Médica Investigadora

• Médica investigadora con postgrado en investigación clínica en Harvard Medical School.
•  Actualmente realizando Doctorado en Ciencias Médicas en Universidad de Chile
• Con 10 años de carrera científica en epilepsia infantil, amplio conocimiento en bioestadísticas, epidemiología, diseño de estudios, data science, escritura científica y educación médica.
• Autora de 32 papers publicados en destacadas revistas internacionales con más de 600 citas en revistas ISI y más de 50 trabajos presentados en congresos internacionales y nacionales. 
• Reconocida con múltiples premios nacionales e internacionales.
• Actualmente desarrollando una tesis sobre la relación entre los hábitos de estilos de vida, el eje microbiota intestino cerebro y cómo esto se relaciona con distintas enfermedades neurológicas, como la epilepsia.

Sheehan T, Amengual-Gual M, Vasquez A, Abend NS, Anderson A, Appavu B, Arya R, Barcia Aguilar C, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Jackson M, Kapur K, Kahoud R, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf AP, Payne ET, Peariso K, Piantino J, Reece L, Riviello JJ, Sands TT, Sannagowdara K, Shellhaas R, Smith G, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T; Pediatric Status Epilepticus Research Group.Epilepsia.
Benzodiazepine administration patterns before escalation to second-line medications in pediatric refractory convulsive status epilepticus. Epilepsia 2021 Aug 21. doi: 10.1111/epi.17043. 

Gaínza-Lein M, Barcia Aguilar C, Piantino J, Chapman KE, Sánchez Fernández I, Amengual-Gual M, Anderson A, Appavu B, Arya R, Brenton JN, Carpenter JL, Clark J, Farias-Moeller R, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Huh L, Kahoud R, Kapur K, Lai YC, McDonough TL, Mikati MA, Morgan LA, Nayak A, Novotny E Jr, Ostendorf AP, Payne ET, Peariso K, Reece L, Riviello J, Sannagowdara K, Sands TT, Sheehan T, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong A, Williams K, Zhang B, Loddenkemper T; Pediatric Status Epilepticus Research Group.
Factors associated with long-term outcomes in pediatric refractory status epilepticus. Epilepsia. 2021 Sep;62(9):2190-2204. doi: 10.1111/epi.16984. Epub 2021 Jul 12. 

Sculier C, Barcia Aguilar C, Gaspard N, Gaínza-Lein M, Sánchez Fernández I, Amengual-Gual M, Anderson A, Arya R, Burrows BT, Brenton JN, Carpenter JL, Chapman KE, Clark J, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Gorman M, Lai YC, McDonough TL, Mikati MA, Nayak A, Peariso K, Riviello J, Rusie A, Sperberg K, Stredny CM, Tasker RC, Tchapyjnikov D, Vasquez A, Wainwright MS, Wilfong AA, Williams K, Loddenkemper T; pSERG.
Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort). Epilepsia. 2021 Jul;62(7):1629-1642. doi: 10.1111/epi.16950. Epub 2021 Jun 6. 

Barcia Aguilar C, Amengual-Gual M, Sánchez Fernández I, Abend NS, Anderson A, Appavu B, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark J, Farias-Moeller R, Gaillard WD, Gaínza-Lein M, Glauser T, Goldstein JL, Goodkin HP, Guerriero RM, Huh L, Lai YC, McDonough TL, Mikati MA, Morgan LA, Novotny EJ, Ostendorf A, Payne ET, Peariso K, Piantino J, Riviello J, Sannagowdara K, Sheehan T, Sands TT, Tasker RC, Tchapyjnikov D, Topjian AA, Vasquez A, Wainwright MS, Wilfong AA, Williams K, Loddenkemper T; pSERG.
Time to Treatment in Pediatric Convulsive Refractory Status Epilepticus: The Weekend Effect. Pediatr Neurol. 2021 Jul;120:71-79. doi: 10.1016/j.pediatrneurol.2021.03.009. Epub 2021 Mar 26. 

Sánchez Fernández I, Amengual-Gual M, Barcia Aguilar C, Gaínza-Lein M.
Descriptive epidemiology and health resource utilization for status epilepticus in the emergency department in the United States of America. Seizure. 2021 Apr;87:7-16. doi: 10.1016/j.seizure.2021.02.020. Epub 2021 Feb 16. 

Iván Sánchez Fernández, Marta Amengual-Gual, Marina Gaínza-Lein, Cristina Barcia Aguilar, Ann Marie Bergin, Christopher J. Yuskaitis, Chellamani Harini.
Cost-effectiveness of adrenocorticotropic hormone versus oral steroids for infantile spasms. Epilepsia. 2021 Feb;62(2):347-357. doi: 10.1111/epi.16799. Epub 2021 Jan 8.

Nicole Nakousi Capurro, Carolina Cares Basualtob, Angélica Alegría Olivos, Marina Gaínza-Lein, Luis López Aristizabal, Alejandro Gayan Torrente, Valentina Ojeda Contreras, María José Irarrázaval Montero.
Anomalías congénitas y comorbilidad en neonatos con Síndrome de Down. Rev Chil Pediatr. 2020;91(5):732-740. 

Iván Sánchez Fernández, Marina Gaínza-Lein, Cristina Barcia Aguilar, Marta Amengual-Gual, Tobias Loddenkemper.
The burden of decisional uncertainty in the treatment of status epilepticus. Epilepsia. 2020 Sep 22. doi: 10.1111/epi.16646. 

Alejandra Vasquez, Marina Gaínza-Lein, Nicholas S Abend, Marta Amengual-Gual, Anne Anderson, Ravindra Arya, J Nicholas Brenton, Jessica L Carpenter, Kevin Chapman, Justice Clark, Raquel Farias-Moeller, William D Gaillard, Tracy Glauser, Joshua L Goldstein, Howard P Goodkin, Rejean M Guerriero, Kush Kapur, Yi-Chen Lai, Tiffani L McDonough, Mohamad A Mikati, Lindsey A Morgan, Edward J Novotny, Adam P Ostendorf, Eric T Payne, Katrina Peariso, Juan Piantino, James J Riviello, Kumar Sannagowdara, Robert C Tasker, Dmitry Tchapyjnikov, Alexis Topjian, Mark S Wainwright, Angus Wilfong, Korwyn Williams, Tobias Loddenkemper, Pediatric Status Epilepticus Research Group (pSERG).
First-line medication dosing in pediatric refractory status epilepticus. Neurology. 2020 Nov 10;95(19):e2683-e2696. 

Iván Sánchez Fernández, Nicholas S Abend, Marta Amengual-Gual, Anne Anderson, Ravindra Arya, Cristina Barcia Aguilar, James Nicholas Brenton, Jessica L Carpenter, Kevin E Chapman, Justice Clark, Raquel Farias-Moeller, William D Gaillard, Marina Gaínza-Lein, Tracy Glauser, Joshua Goldstein, Howard P Goodkin, Réjean M Guerriero, Yi-Chen Lai, Tiffani McDonough, Mohamad A Mikati, Lindsey A Morgan, Edward Novotny Jr, Eric Payne, Katrina Peariso, Juan Piantino, Adam Ostendorf, Tristan T Sands, Kumar Sannagowdara, Robert C Tasker, Dimtry Tchapyjnikov, Alexis A Topjian, Alejandra Vasquez, Mark S Wainwright, Angus Wilfong, Kowryn Williams, Tobias Loddenkemper, pSERG.
Association of guideline publication and delays to treatment in pediatric status epilepticus. Neurology. 2020 Sep 1;95(9):e1222-e1235. 

Iván Sánchez Fernández, Marina Gaínza-Lein, Nicholas S. Abend, Marta Amengual-Gual, Anne Anderson, Ravindra Arya, J. Nicholas Brenton, Jessica L. Carpenter, Kevin E. Chapman, Justice Clark, Raquel Farias-Moeller, William Davis Gaillard, Tracy A. Glauser, Joshua Goldstein, Howard P. Goodkin, Réjean M. Guerriero, Kurt Hecox, Michele Jackson, Kush Kapur, Sarah A. Kelley, Eric H.W. Kossoff, Yi-Chen Lai, Tiffani L. McDonough, Mohamad A. Mikati, Lindsey A. Morgan, Edward J. Novotny, Adam P. Ostendorf, Eric T. Payne, Katrina Peariso, Juan Piantino, James J. Riviello Jr., Kumar Sannagowdara, Carl E. Stafstrom, Robert C. Tasker, Dmitry Tchapyjnikov, Alexis A. Topjian, Alejandra Vasquez, Mark S. Wainwright, Angus Wilfong, Korwyn Williams, Tobias Loddenkemper, on behalf of the Pediatric Status Epilepticus Research Group.
The onset of pediatric refractory status epilepticus is not distributed uniformly during the day. Seizure Volume 70, August 2019, Pages 90-96. 

Sansevere AJ, Arya R, Sánchez Fernández I, Gaillard WD, Tasker RC, Lai YC, Anderson AE, Tchapyjnikov D, Chapman KE, Brenton JN, Carpenter JL, Gaínza-Lein M, Goldstein JL, Goodkin HP, Jackson MC, Kapur K, Mikati MA, Peariso K, Glauser TA, Topjian AA, Wainwright M, Wilfong AA, Williams KL, Loddenkemper T, Abend NS; Pediatric Status Epilepticus Research Group (pSERG).
Electroencephalographic Reporting for Refractory Status Epilepticus. J Clin Neurophysiol. 2019 Sep;36(5):365-370. 

Iván Sánchez Fernández, Tobias Loddenkemper, Marina Gaínza-Lein, Beth Rosen Sheidley, Annapurna Poduri.
Diagnostic yield of genetic tests in epilepsy. A meta-analysis, and cost-effectiveness study. Neurology. 2019 Jan 4;92(5):e418-e428. 

Iván Sánchez Fernández, Marina Gaínza-Lein, Nathan Lamb, Tobias Loddenkemper.
Meta-analysis and cost-effectiveness of second-line antiepileptic drugs for status epilepticus. Neurology. 2019 May 14;92(20):e2339-e2348. 

Alberto Fica, Viviana Sotomayor, Rodrigo Fasce, Jeannette Dabanch, Andrés Soto, Paulo Charpentier, Gonzalo Guerrero, Felipe Olivares, Vjera Triantafilo, Nathalie El Omeiri,  Marina Gaínza-Lein.
Severe acute respiratory infections (SARI) from influenza in adult patients in Chile: the experience of a sentinel hospital. Pan American Journal of Public Health. January 2019. 

Claudine Sculier, Marina Gaínza-Lein, Iván Sánchez Fernandez, Tobias Loddenkemper.
Long term consequences of intensive care treatments in status epilepticus - a critical assessment. Epilepsia. 2018 August 26. 

Alejandra Vasquez, Marina Gaínza-Lein, Ivan Sánchez Fernandez, Nicholas S. Abend, Anne Anderson, J Nicholas Brenton, Jessica L. Carpenter, Kevin Chapman, Justice Clark, William D. Gaillard, Tracy Glauser, Joshua Goldstein, Howard P. Goodkin, Yi-Chen Lai, Tobias Loddenkemper, Tiffani L. McDonough, Mohamad A. Mikati, Anuranjita Nayak, Eric Payne, James Riviello, Dmitry Tchapyjnikov, Alexis Topjian, Mark Wainwright, Robert C. Tasker, on behalf of the Pediatric Status Epilepticus Research Group (pSERG).
Hospital emergency treatment of convulsive status epilepticus: comparison of pathways from ten pediatric research centers. Pediatric Neurology. 11 July 2018. 

Marina Gaínza-Lein, Iván Sánchez Fernandez, Adriana Campos-Ulate, Tobias Loddenkemper, Adam Ostendorf.
Timing in the Treatment of Status Epileptics: From Basics to the Clinic. Seizure. 2018 Jun 1. pii: S1059-1311(18)30235-8. 

Saba Jafarpour, Lawrence J. Hirsch, Marina Gaínza-Lein, Christoph Kellinghaus, Kamil Detyniecki.
Seizure cluster: definition, prevalence, consequences, and management. Seizure. 2019 May;68:9-15. doi: 10.1016/j.seizure.2018.05.013. Epub 2018 May 21. 

Iván Sánchez Fernández, Arnold Sansevere, Marina Gaínza-Lein, Kush Kapur, Tobias Loddenkemper.
Machine learning for outcome prediction in the pediatric intensive care unit. J Child Neurol. 2018 Jul;33(8):546-553. doi: 10.1177/0883073818773230. Epub 2018 May 13.

Ravindra Arya, Katrina Peariso, Marina Gaínza-Lein, Jessica Harvey, Ann Bergin, James N. Brenton, Brian T. Burrows, Tracy Glauser, Howard P. Goodkin, Yi-Chen Lai, Mohamad A. Mikati, Ivan Sanchez-Fernandez, Dmitry Tchapyjnikov, Angus A. Wilfong, Korwyn Williams, Tobias Loddenkemper, for the pediatric Status Epilepticus Research Group (pSERG).
Efficacy and safety of ketogenic diet for treatment of pediatric convulsive refractory status epilepticus. Epilepsy Res. 2018 Aug;144:1-6. doi: 10.1016/j.eplepsyres.2018.04.012. Epub 2018 Apr 27.

Daniel Goldenholz, Kshitiz Rakesh, Kush Kapur, Marina Gaínza-Lein, Ryan Hodgeman, Robert Moss, William H Theodore, Tobias Loddenkemper.
Different as Night and Day: Isolated Seizures, Clusters, and Status Epilepticus. Epilepsia. 2018 May;59(5):e73-e77. doi: 10.1111/epi.14076. Epub 2018 Apr 23.

Sánchez Fernández I, Gaínza-Lein M, Abend NS, Anderson, A, Arya R, Brenton JN, Carpenter JL, Chapman KE, Clark, J, Gaillard WD, Glauser TA, Goldstein JL, Goodkin HP, Reynolds (Helseth) A, Jackson MC, Kapur K, Lai, Y-C, McDonough TL, Mikati MA, Nayak, A, Peariso K, Riviello JJ Jr, Tasker RC, Tchapyjnikov D, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T, on behalf of Pediatric Status Epilepticus Research Group (pSERG).
Factors associated with treatment delays in pediatric refractory convulsive status epilepticus. Neurology. 2018 May 8;90(19):e1692-e1701. doi: 10.1212/WNL.0000000000005488. Epub 2018 Apr 11.

Marina Gaínza-Lein, Iván Sánchez Fernández, Michele Jackson, Nicholas Abend, Ravindra Arya, J. Nicholas Brenton, Jessica Carpenter, Kevin Chapman, William Gaillard, Tracy Glauser, Joshua Goldstein, Howard Goodkin, Kush Kapur, Mohamad Mikati, Katrina Peariso, Robert Tasker, Dmitry Tchapyjnikov, Alexis Topjian, Mark Wainwright, Angus Wilfong, Korwyn Williams, Tobias Loddenkemper, on behalf of Pediatric Status Epilepticus Research Group (pSERG).
Association of Time to Treatment with Short-term Outcomes for Pediatric Patients with Refractory Convulsive Status Epilepticus. JAMA Neurol. 2018 Jan 22. 

Iván Sánchez Fernández, Arnold Sansevere, Marina Gaínza-Lein, Ersida Buraniqi, Robert C Tasker, Tobias Loddenkemper.
Time to continuous electroencephalogram in repeated admissions to the pediatric intensive care unit. Seizure. 2018 Jan;54:19-26. 

Marina Gaínza-Lein, Robert Benjamin, Coral Stredny, Marlee McGurl, Tobias Loddenkemper.
Rescue medications in the epileptic population: the family perspective. Seizure. 2017 Oct 13; 52:188-194. 

Monisha Sachdev, Marina Gaínza-Lein, Dmitry Tchapyjnikov, Tobias Loddenkemper, Mohamad A. Mikati.
Novel clinical manifestations in patients with KCNA2 mutations. Seizure. 2017 Aug 5;51:74-76. 

Iván Sánchez Fernández, Marina Gaínza-Lein, Tobias Loddenkemper.
Nonintravenous rescue medications for pediatric status epilepticus: A cost-effectiveness analysis. Epilepsia. 2017 Jun 16. 

Marina Gaínza-Lein, Iván Sánchez Fernández, Tobias Loddenkemper.
Use of EEG in critically ill children and neonates in the United States of America from 2010-2012. J Neurol. 2017 Jun;264(6):1165-1173. 

Sánchez Fernández I*, Jackson MC*, Abend NS, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Gaínza-Lein M, Glauser TA, Goldstein JL, Goodkin HP, Helseth A, Kapur K, McDonough TL, Mikati MA, Peariso K, Riviello J Jr, Tasker RC, Topjian AA, Wainwright MS, Wilfong A, Williams K, Loddenkemper T, on behalf of Pediatric Status Epilepticus Research Group (pSERG).
Refractory status epilepticus in children with and without prior epilepsy or status epilepticus. Neurology, December 23, 2016. 

Mohammadpour Touserkani F, Gaínza-Lein M, Jafarpour S, Brinegar K, Kapur K, Loddenkemper T.
HHV-6 and seizure: A systematic review and meta-analysis. J Med Virol. 2017 Jan;89(1):161-169. 

Ulate-Campos A, Coughlin F, Gaínza-Lein M, Fernandez IS, Pearl PL, Loddenkemper T.
Automated seizure detection systems and their effectiveness for each type of seizure. Seizure 2016;40:88-101.

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